Adverse reactions on contrast agents are rare, but like all other pharmaceuticals, contrast media are not completely without side effects.
Adverse effects to contrast media include allergic symptoms, anaphylactoid reactions, chemotoxic reactions, idiosyncratic reactions, contrast-induced nephropathy, iodide-induced hyperthyroidism and local tissue damage. An adverse reaction can be related to dose, the toxicity, and the physio-chemical properties of the contrast agent, for example osmolality, viscosity, and hydrophilicity.
Side effects such as a metallic taste in the mouth, generalized warmth or flushing, nausea and vomiting, increase with rapid flow and large volume of the injected agent. Although venous tolerance is usually good, there have been reports of sensation like burning, stinging or numbness and of venospasm.

Characterization of adverse reactions include:

An anaphylactic reaction is a generalized allergic effect (also called anaphylactic shock). Allergic or anaphylactoid reactions range from sneezing, urticaria and itching, bronchospasm, facial and laryngeal edema to life-threatening symptoms including cardiovascular collapse, shock and respiratory distress.
Iodinated contrast materials are safe and widely used. However, anaphylactoid reactions occur rarely after administration of x-ray contrast agents. Most hypersensitivity symptoms appear short time after the intravenous, oral, rectal or other application (e.g., retrograde pyelography), only few are delayed by hours.
Patients with a history of allergic, asthmatic or reactions to contrast agents are at increased risk of anaphylaxis. Pre-treatment with corticosteroids and antihistamines decreases the incidence of an adverse reaction.

(ALARA) 'As low as reasonably achievable' is a precautionary principle that should be part of basic radiation safety considerations in protection to the exposure as well as in other technologies of the medical, the nuclear and the industrial fields.
ALARA is based on three principles: Justification means that possible exposure to humans should yield a sufficient benefit to society to justify the risks of the radiation exposure. The ICRP in 1977 states that 'all exposures shall be kept as low as reasonably achievable, economic and social factors being taken into account'. The radiation exposure must be reduced to the lowest level possible, considering the costs of such a limitation in dose.

Breast imaging methods include mammography (mammogram), ultrasound, breast MRI, positron emission tomography, xeromammography, diaphanography and thermography.
Mammography is widely used as a screening method and diagnostic tool for breast cancer detection or evaluation of breast disease. Digital mammography takes multiple thin digital image 'slices' through the breast, which provides higher potential to see a small mass within dense tissue. The mammography quality standards act guarantees a high image quality.
Breast ultrasound (also called ultrasonography) should only be used as an additional imaging modality to evaluate specific breast abnormalities, especially to differentiate cystic from solid masses. Ultrasound is also used to guide needle breast biopsies.
Magnetic resonance imaging (MRI) is useful for breast MRI screening in cases of high cancer risk. In addition, multifocal breast cancer can be missed by standard practice mammography and can be early detected with breast MRI.

Classification by the Food and Drug Administration (FDA) of medical devices according to potential risks or hazards.