(MPI) The myocardial perfusion scan is the most common nuclear medicine procedure in cardiac imaging and allows assessing the blood-flow patterns to the heart muscles. The comparison of the radiopharmaceutical distribution after stress and at rest provides information on myocardial viability and cardiac perfusion abnormalities. ECG-gated myocardial perfusion imaging allows the assessment of global and regional myocardial function such as wall motion abnormalities.
The diagnostic accuracy of myocardial perfusion scintigraphy (also abbreviated MPS) allows reliable risk stratification and guides the selection of patients for further interventions, such as revascularization. MPI also has particular advantages over alternative techniques in the management of a number of patient subgroups, including women, the elderly, and those with diabetes. The use of this type of cardiac scintigraphy is associated with greater cost effectiveness of treatment, in terms of life-years saved, particularly in these special patient groups.
Myocardial perfusion scintigrams are acquired with a gamma camera. Single photon emission computed tomography (SPECT) is preferred over planar imaging because of the three dimensional nature of the images and their superior contrast resolution.
Common MPI radiopharmaceuticals, approved by the U.S. Food and Drug Administration (FDA) include: Tl-201 and the Tc-99m-labeled radiopharmaceuticals, such as sestamibi, tetrofosmin, and teboroxime for single-photon imaging. Rb-82 is used for positron emission tomography (PET) imaging.

See also Gated Blood Pool Scintigraphy, Myocardial Late Enhancement, Cardiac MRI and Echocardiography.

[Rest Mass Energy] The term refers to the concept of mass-energy equivalence. Einstein proposed that the equivalence of mass and energy is a general principle.
E=mc²
E = energy,
m = mass,
c = the speed of light in a vacuum.
c² is the conversion factor required to convert from units of mass to units of energy.
The rest energy of an electron or a positron for example amounts to 0.511 MeV.

See also Photon, Photon Energy.

Tomography is imaging by sections or sectioning to obtain images of slices through objects like the human body. Tomography is derived from the Greek words 'to cut or section' (tomos) and 'to write' (graphein). A device used in tomography is called a tomograph, while the image produced is a tomogram.
The first medical applications utilized x-rays for images of tissues based on their x-ray attenuation coefficient. The mathematical basis for tomographic imaging was laid down by Johann Radon. This type of imaging is used in different medical applications as for example computed tomography, ultrasound imaging, positron emission tomography and magnetic resonance imaging (MRI) also called magnetic resonance tomography (MRT).
Conventional x-ray tomographic techniques show organ structures lying in a predetermined plane (the focal plane), while blurring the tissue structures in planes above and below by linear or complex geometrical motion of the x-ray tube and film cassette.
Basically, computed tomography is the reconstruction of an image from its projections. In the strict sense of the word, a projection at a given angle is the integral of the image in the direction specified by that angle. The CT images (slices) are created in the axial plane, while coronal and sagittal images can be rendered by computer reconstruction.

See also Zonography, Computed or Computerized Axial Tomography, Resolution Element, Radiographic Noise, Intravenous Pyelogram.