Radiation can ionize matter caused by the high energy which displaces electrons during interactions with atoms. In the electromagnetic spectrum higher frequency ultraviolet radiation begins to have enough energy to ionize matter.
Examples of ionizing radiation include alpha particles, beta particles, gamma rays, x-rays, neutrons, high-speed electrons, high-speed protons, and other particles capable of producing ions by direct or secondary processes in passage through tissues.
Damage of living tissue results from the transfer of energy to atoms and molecules in the cellular structure. Ionized cells have to repair themselves to remain alive. Generally, healthy cells have a higher capability to repair themselves than cancer cells.

Biological effects of ionizing radiation exposure:
Ionizing radiation are used in a wide range of facilities, including health care, research institutions, nuclear reactors and their support facilities, and other manufacturing settings. These radiation sources can pose a serious hazard to affected people and environment if not properly controlled.

See also Radiation Safety, Controlled Area, Radiotoxicity and As Low As Reasonably Achievable.

The process of pair production is the creation of a particle and its antiparticle. If a photon with a minimum energy of the rest mass of an electron and a positron hits a nucleus an electron and a positron is emitted. The surplus energy appears as the kinetic energy of the two created particles. Conservation of energy and momentum makes pair production possible or not.

An anion is a negative charged ion; the atom has more electrons than protons. Anions are attracted from the positively charged anode. This is a basic part for producing radiation in the x-ray tube.

Annihilation in general refers to the transition of a particle and its antiparticle by collision into something different, depending on their energies and based on the conservation of energy and momentum. The electromagnetic radiation emitted is the result of the annihilation (combination and disappearance) of an electron and a positron. Two gamma rays of 0.511 MeV energy, assuming very low-energy particles, are emitted perpendicular to each other.

(ACD) Caused by positron decay and positron annihilation two photons are emitted each with an energy of 511 keV in opposite directions. The simultaneous detection of these two photons, by two detectors indicates that a positron annihilation occurred at the line of response (LOR), the path between the two detectors.
In PET imaging the annihilation coincidence detection is used to localize the tracer, e.g. F18.

See also Positron Decay and Electron Positron Annihilation.