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Biliscopin® Infusion
Biliscopin® Infusion, an iodinated contrast medium for intravenous cholecystography is secreted actively by the hepatocytes. The biliary excretion rate of a biliary contrast medium is determined by the binding to plasma proteins and liver receptor proteins, and by its transport maximum for the liver. Because of its high hepatocellular transport rate, Biliscopin® Infusion leads rapidly to high grade contrast density in the intra-hepatic and extra-hepatic biliary ducts as well as in the gallbladder.
Computed tomography with biliary contrast agents provides maximum quality preoperative imaging of the biliary tract.

Drug Information and Specification
NAME OF COMPOUND
Meglumine iotroxate
INDICATION
Cholecystography, cholecystangiography
APPLICATION
Intravenous
PHARMACOKINETIC
Biliary excretion
0.29 mosm/kgH2O
IODINE CONCENTRATION
105 mg/mL
100 mL
PREPARATION
Ready-to-use product
STORAGE
Protect from light and x-rays
PRESENTATION
100 mL bottle
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Cholografin® Meglumine
Cholografin® Meglumine is a contrast agent for intravenous cholangiography and cholecystography. Iodipamide's primary excretion through the hepato-biliary system and concentration in bile allows visualization of the gallbladder and biliary ducts.

Drug Information and Specification
NAME OF COMPOUND
Iodipamide meglumine
DEVELOPER
Bracco Diagnostics, Inc.
INDICATION
Cholecystography, cholecystangiography
APPLICATION
Intravenous
PHARMACOKINETIC
Biliary excretion
IODINE CONCENTRATION
520 mg/mL
20 mL
PREPARATION
Ready-to-use product
STORAGE
Protect from light; store at 20°-25°Celsius (68°-77°Fahrenheit); avoid excessive heat.
PRESENTATION
20 mL vials
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Conray®
Conray® is a contrast agent intended for intravascular administration as a diagnostic radiopaque medium. Conray® is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine by glomerular filtration.
See also Ionic Contrast Agents, Contrast Media Injector, Dual-Head CT Power Injector, CT Power Injector.

Drug Information and Specification
NAME OF COMPOUND
Iothalamate sodium
DEVELOPER
Mallinckrodt, Inc.
INDICATION
Brain and body computed tomography, urography, angiography
APPLICATION
Intravascular
PHARMACOKINETIC
Renal excretion
CHEMICAL BOND
2300 mosm/kgH2O
IODINE CONCENTRATION
400 mg/mL
1.5 mL/kg
PREPARATION
Ready-to-use product
STORAGE
Store below 30°Celsius (86°Fahrenheit)
PRESENTATION
50 mL vials, 50 mL prefilled plastic syringes
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Cystografin®
Cystografin® (USP30% or Cystografin®-Dilute USP 18%) is a radiopaque contrast agent for retrograde cystourethrography. Cystografin® is not intended for intravascular injection.

Drug Information and Specification
NAME OF COMPOUND
Diatrizoate meglumine 300mg/mL
DEVELOPER
Bracco Diagnostics, Inc.
INDICATION
Retrograde cystourethrography
APPLICATION
Intravesical
IODINE CONCENTRATION
141 mg/mL
25 to 300 mL
PREPARATION
Ready-to-use product
STORAGE
Store at 20-25°Celsius (68-77°Fahrenheit), protect from light
PRESENTATION
100 and 300 mL bottle
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Diagnostic Imaging
Imaging refers to the visual representation of an object. Today, diagnostic imaging uses radiology and other techniques, mostly noninvasive, to create pictures of the human body. Diagnostic radiography studies the anatomy and physiology to diagnose an array of medical conditions. The history of medical diagnostic imaging is in many ways the history of radiology. Many imaging techniques also have scientific and industrial applications. Diagnostic imaging in its widest sense is part of biological science and may include medical photography, microscopy and techniques which are not primarily designed to produce images (e.g., electroencephalography and magnetoencephalography).
Brief overview about important developments:
Imaging used for medical purposes, began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette.
In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This diagnostic imaging technology allows information of biologic processes in vivo. Today, single photon emission computed tomography (SPECT) and positron emission tomography (PET) play an important role in both clinical research and diagnosis of biochemical and physiologic processes.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasound has been imported into practically every area of medicine as an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast imaging, real-time 3D or 4D ultrasound, and molecular imaging. The earliest use of ultrasound contrast agents (USCA) was in 1968.
The introduction of computed tomography (CT/CAT) in the 1970s revolutionized medical imaging with cross sectional images of the human body and high contrast between different types of soft tissues. These developments were made possible by analog to digital converters and computers. First, spiral CT (also called helical), then multislice CT (or multi-detector row CT) technology expanded the clinical applications dramatically.
The first magnetic resonance imaging (MRI) devices were tested on clinical patients in 1980. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.

Today, imaging in medicine has been developed to a stage that was inconceivable a century ago, with growing modalities:
x-ray projection imaging, including conventional radiography and digital radiography;
scintigraphy;
single photon emission computed tomography;
positron emission tomography.

All these types of scans are an integral part of modern healthcare. Usually, a radiologist interprets the images. Most clinical studies are acquired by a radiographer or radiologic technologist. In filmless, digital radiology departments all images are acquired and stored on computers. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in a picture archiving and communication system (PACS). In telemedicine, medical images of MRI scans, x-ray examinations, CT scans and ultrasound pictures are transmitted in real time.

See also Interventional Radiology, Image Quality and CT Scanner.
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 [last update: 2023-11-06 02:01:00]