A depletion test is a rarely accomplished study, used to detect deficiency in iodine organification.

Diaphanography is a noninvasive breast imaging technique used in diagnosis of breast disease. The breast is illuminated with low intensity light and the transmission pattern of red and near-infrared radiation is detected. After amplification and reconstruction, the images are displayed on a monitor.
Results from diaphanography tend to show lower sensitivities and specificities than are found in diagnostic mammography studies. Light scanning (diaphanography and transillumination) is not recommended for screening or diagnostic evaluation of the breast.

In radiology dose is the term for radiation related to the amount of energy absorbed in matter (for example absorbed dose, acute dose, effective dose, external dose, personal dose and committed dose equivalent). The SI standard unit of radiation dose is the gray.
Dose refers also to the amount of medication, radiopharmaceutical or contrast medium used in diagnostic imaging.

See also Deep Dose Equivalent, Critical Organ, Eye Dose Equivalent, Collective Effective Dose, Medical Internal Radiation Dose Committee, and Chronic Dose.

Dosimetrists calculate the dose of radiation. To secure sufficient tumor destruction while sparing the normal tissues, a number of (often) complex treatment plans are developed.
The Medical Dosimetrist Certification Board certifies dosimetrists. Dosimetrists work with the physician and the medical physicist to choose the treatment plan that is best for each patient. A dosimetrist may start as a radiation therapist and become with intensive training a dosimetrist. Others are graduates of dosimetry programs.

Different stages of the drug development and approval process in the USA, lead from preclinical trials (testing in animals), first application in humans through limited and broad clinical tests, to postmarketing studies.

	Years	Test Population	Purpose	Success Rate
Preclinical Testing	3.5	Laboratory and animal studies	Assess safety and biological activity	5,000 compounds evaluated
File IND at FDA
Phase I	1	20 to 80 healthy volunteers	Determine safety and dosage	5 enter trials
Phase II	2	100 to 300 patient volunteers	Evaluate effectiveness, look for side effects
Phase III	3	1000 to 3000 patient volunteers	Verify effectiveness, monitor adverse reactions from long-term use
File NDA at FDA
FDA	2.5	Review process / Approval		1 approved
	12 Total
Phase IV	Additional Post marketing testing required by FDA

By Dale E. Wierenga, Ph.D. and C. Robert Eaton
Office of Research and Development
Pharmaceutical Manufacturers Association

'In reviewing this report, it is important to keep in mind the realities of the drug discovery and development process. The U.S. system of new drug approvals is perhaps the most rigorous in the world. On average, it costs a company $359 million to get one new medicine from the laboratory to the pharmacist's shelf, according to a February 1993 report by the Congressional Office of Technology Assessment.'

See also Phase 1 2 3 4 Drug Trials, Clinical Trial, Food and Drug Administration, and European Medicines Agency.